Publications

full publication list

selected reviews

Transcriptomic insights into human brain evolution: acceleration, neutrality, heterochrony
Somel M, Rohlfs R, Liu X (2014) Curr Opin Genet Dev. download pdf

Human brain evolution: transcripts, metabolites and their regulators
Somel M, Liu X, Khaitovich P (2013) Nature Reviews Neuroscience 14, 112-127. download pdf

The role of neoteny in human evolution: from genes to the phenotype.
Somel M, Tang L, Khaitovich P (2010) In Post-Genome Biology of Primates. H. Hirai, H. Imai,Y. Go (Eds.). Springer, Berlin

selected research articles

The Demographic Development of the First Farmers in Anatolia
Gülşah Merve Kılınc, Ayça Omrak, FüsunÖzer, Torsten Günther, Ali Metin Büyükkarakaya, Erhan Bıçakçı, Douglas Baird,Handan Melike Dönertaş, Ayshin Ghalichi, Reyhan Yaka, Dilek Koptekin, Sinan Can Açan, Poorya Parvizi, Maja Krzewinska, Evangelia A. Daskalaki, Eren Yüncü, Nihan Dilşad Dagtaş, Andrew Fairbairn, Jessica Pearson, Gökhan Mustafaoglu, Yılmaz Selim Erdal, Yasin Gökhan Çakan, İnci Togan, Mehmet Somel*, Jan Stora, Mattias Jakobsson and Anders Götherström. (2016) Current Biology 2659:2666
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Determining the origin of synchronous multifocal bladder cancer by exome sequencing.
Acar Ö*, Özkurt E*, Demir G, Saraç H, Alkan C, Esen T, Somel M*, Lack NA*. (2015) BMC Cancer  15:871 
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Whole genome sequencing of Turkish genomes reveals functional private alleles and impact of genetic interactions with Europe, Asia and Africa.
Alkan C, Kavak P, Somel M, Gokcumen O, Ugurlu S, Saygi C, Dal E, Bugra K, Güngör T, Sahinalp SC, Özören N, Bekpen C.
 (2014) BMC Genomics 15:963 view full text

Evolution of Human Longevity Uncoupled from Caloric Restriction Mechanisms.
Zhao G, Guo S, Somel M* and Khaitovich P* (2014) PLoS ONE 9(1):e84117 view full text

A Scan for Human-Specific Relaxation of Negative Selection Reveals Unexpected Polymorphism in Proteasome Genes.
Somel M, Wilson Sayres MA, Jordan G, Huerta-Sanchez E, Fumagalli M, Ferrer-Admetlla A, Nielsen R. (2013) Molecular Biology & Evolution 7(8):e43915 view full text

Mechanisms of dietary response in mice and primates: A role for EGR1 in regulating the reaction to human-specific nutritional content.
Weng K, Hu HY, Xu AG, Khaitovich P* and Somel M* (2012) PLoS ONE 7(8):e43915 view full text

Accelerated aging-related transcriptome changes in the female prefrontal cortex.
Yuan Y, Chen YPP, Khaitovich P*, Somel M* (2012) Aging Cell 12(1):347 view full text

Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques.
Liu X*, Somel M*, Tang L*, Giavalisco P, Eckardt A, Yan Z, Fu N, Guo S, Hu HY, Fu X, Yuan Y, Ning Z, Li N, Menzel C, Zeng R, Chen W, Willmitzer L, Pääbo S, Khaitovich P (2012) Genome Research 22(4):611-22 view full text

MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates.
Somel M*, Liu X*, Tang L, Yan Z, Hu HY, Guo S, Xu GH, Xie GC, Li N, Hu Y, Chen W, Pääbo S, Khaitovich P (2011) PLoS Biology 9(12): e1001214 view full text

Development and application of a modified dynamic time warping algorithm (DTW-S) to analyses of primate brain expression time series.
Yuan Y, Chen YP, Ni S, Xu AG, Tang L, Vingron M, Somel M, Khaitovich P (2011) BMC Bioinformatics 12(1):347 view full text

MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain.
Somel M*, Guo S*, Fu N*, Yan Z, Hu HY, Fu X, Yuan Y, Ning Z, Hu Y, Menzel C, Hu H, Lachmann M, Zeng R, Chen W, Khaitovich P (2010) Genome Research 20: 1207-1218 view full text

Transcriptional Neoteny in the Human Brain.
Somel M, Franz H, Yan Z, Lorenc A, Guo S, Giger T, Kelso J, Nickel B, Dannemann M, Bahn S, Webster MJ, Weickert CS, Lachmann M, Pääbo S, Khaitovich P (2008) Proc Natl Acad Sci U S A 106(14):5743-8 view full text

Human and chimpanzee gene expression differences replicated in mice fed different diets.
Somel M*, Creely H*, Franz H, Mueller U, Lachmann M, Khaitovich P, Pääbo S. (2008) PLoS ONE 30;3(1):e1504 view full text

Gene expression becomes heterogeneous with age.
Somel M, Khaitovich P, Bahn S, Pääbo S, Lachmann M. (2006) Current Biology 16(10):R359-60 download pdf

other recent work

Determining the origin of synchronous multifocal bladder cancer by exome sequencing..
Acar Ö, Özkurt E, Demir G, Saraç H, Alkan C, Esen T, Somel M, Lack NA (2015) BMC Cancer  link

Whole genome sequencing of Turkish genomes reveals functional private alleles and impact of genetic interactions with Europe, Asia and Africa.
Alkan C, Kavak P, Somel M, Gokcumen O, Ugurlu S, Dal E, Buğra-Bilge K, Güngör T, Sahinalp SC, Özören N, Bekpen C. (2014) BMC Genomics  link

Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA.
Huerta-Sánchez E,  Jin X, Asan, Bianba Z, Peter BM, Vinckenbosch N, Liang Y, Yi X, He M, Somel M, Ni P, Wang B, Ou X, Huasang, Luosang J, Cuo ZXP, Li K, Gao G, Yin Y, Wang W, Zhang X, Xu X, Yang H, Li Y, Wang J, Wang J, Nielsen R (2014) Nature 10.1038/nature13408 link

Shared signatures of social stress and aging in peripheral blood mononuclear cell gene expression profiles.
Snyder‐Mackler N,
Somel M, Tung J (2014) Aging Cell 10.1111/acel.12239 view full text

Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears.
Liu S, Lorenzen ED, Fumagalli M, Li B, Harris K, Xiong Z, Zhou L, Korneliussen TS, Somel M, Babbitt C, Wray G, Li J, He W, Wang Z, Fu W, Xiang X, Morgan CC, Doherty A, O’Connell MJ, McInerney JO, Born EW, Dalén L, Dietz R, Orlando L, Sonne C, Zhang G, Nielsen R, Willerslev E, Wang J. (2014) Cell ;157(4):785-94. link

Classic selective sweeps revealed by massive sequencing in cattle.
Qanbari S, Pausch H, Jansen S, Somel M, Strom TM, Fries R, Nielsen R, Simianer H (2014) PLoS Genetics 10(2):e1004148 view full text

 

 

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