An explanation for the sister repulsion phenomenon in Patterson’s f-statistics
Gözde Atağ, Shamam Waldman, Shai Carmi, Mehmet Somel (2024) Genetics, iyae144
[PREPRINT] DeepKin: Predicting relatedness from low-coverage genomes and paleogenomes with convolutional neural networks
Merve N. Güler, Ardan Yılmaz, Büşra Katırcıoğlu, Sarp Kantar, Tara Ekin Ünver, Kıvılcım Başak Vural, N. Ezgi Altınışık, Emre Akbaş, Mehmet Somel (2024) bioRxiv, 2024.08.08.607159
Investigating food production-associated DNA methylation changes in paleogenomes: Lack of consistent signals beyond technical noise
Sevim Seda Çokoğlu, Dilek Koptekin, Fatma Rabia Fidan, Mehmet Somel (2024) Evolutionary Applications, 17, e13743
The first complete genome of the extinct European wild ass (Equus hemionus hydruntinus)
Mustafa Özkan, Kanat Gürün, Eren Yüncü, Kıvılcım Başak Vural, Gözde Atağ, Ali Akbaba, Fatma Rabia Fidan, Ekin Sağlıcan, Ezgi N. Altınışık, Dilek Koptekin, Kamilla Pawłowska, Ian Hodder, Sarah E. Adcock, Benjamin S. Arbuckle, Sharon R. Steadman, Gregory McMahon, Yılmaz Selim Erdal, C. Can Bilgin, İnci Togan, Eva-Maria Geigl, Anders Götherström, Thierry Grange, Füsun Özer, Mehmet Somel (2024) Molecular Ecology, 33, e17440
[PREPRINT] Out-of-Anatolia: cultural and genetic interactions during the Neolithic expansion in the Aegean
Dilek Koptekin, Ayça Aydoğan, Cansu Karamurat, N. Ezgi Altınışık, Kıvılcım Başak Vural, D. Deniz Kazancı, Ayça Küçükakdağ Doğu, Damla Kaptan, Hasan Can Gemici, Eren Yüncü, Gülsün Umurtak, Refik Duru, Erkan Fidan, Özlem Çevik, Burçin Erdoğu, Taner Korkut, Christopher J. Knusel, Scott D. Haddow, Clark Spencer Larsen, Rana Özbal, Fokke Gerritsen, Eylem Özdoğan, Uygar Ozan Usanmaz, Yasin Cemre Derici, Mine Uçmazoğlu, Flora Jay, Mehmet Özdoğan, Anders Götherström, Yılmaz Selim Erdal, Anna-Sapfo Malaspinas, Çiğdem Atakuman, Füsun Ozer, Mehmet Somel (2024) bioRxiv 2024.06.23.599747
[PREPRINT] Female lineages and changing kinship patterns in Neolithic Çatalhöyük
Eren Yüncü, Ayça Küçükakdağ Doğu, Damla Kaptan, Muhammed Sıddık Kılıç, Camilla Mazzucato, Merve N. Güler, Elifnaz Eker, Büşra Katırcıoğlu, Maciej Chyleński, Kıvılcım Başak Vural, Arda Sevkar, Gözde Atağ, N. Ezgi Altınışık, Fatma Küçük Baloğlu, Defne Bozkurt, Jessica Pearson, Marco Milella, Cansu Karamurat, Şevval Aktürk, Ekin Sağlıcan, Nisan Yıldız, Dilek Koptekin, Sevgi Yorulmaz, Duygu Deniz Kazancı, Ayça Aydoğan, Nergis Bilge Karabulut, Kanat Gürün, Eline M.J. Schotsmans, Jana Anvari, Eva Rosenstock, Jennifer Byrnes, Peter F. Biehl, David Orton, Vendela Kempe Lagerholm, Hasan Can Gemici, Milena Vasic, Arkadiusz Marciniak, Çiğdem Atakuman, Yılmaz Selim Erdal, Emrah Kırdök, Marin Pilloud, Spencer Larsen, Scott D. Haddow, Anders Götherström, Christopher J. Knüsel, Füsun Özer, Ian Hodder, Mehmet Somel (2024) bioRxiv 2024.06.23.600259
Ancient Sheep Genomes reveal four Millennia of North European Short-Tailed Sheep in the Baltic Sea region
Martin N. A. Larsson, Pedro Morell Miranda, Li Pan, Kıvılcım Başak Vural, Damla Kaptan, André Elias Rodrigues Soares, Hanna Kivikero, Juha Kantanen, Mehmet Somel, Füsun Özer, Anna M. Johansson, Jan Storå, Torsten Günther (2024) Genome Biology and Evolution, evae114
Benchmarking kinship estimation tools for ancient genomes using pedigree simulations
Şevval Aktürk, Igor Mapelli, Merve N. Güler, Kanat Gürün, Büşra Katırcıoğlu, Kıvılcım Başak Vural, Ekin Sağlıcan, Mehmet Çetin, Reyhan Yaka, Elif Sürer, Gözde Atağ, Sevim Seda Çokoğlu, Arda Sevkar, N. Ezgi Altınışık, Dilek Koptekin, Mehmet Somel (2024) Molecular Ecology Resources, 00, e13960
Population genomic history of the endangered Anatolian and Cyprian mouflons in relation to worldwide wild, feral and domestic sheep lineages
Gözde Atağ, Damla Kaptan, Eren Yüncü, Kıvılcım Başak Vural, Paolo Mereu, Monica Pirastru, Mario Barbato, Giovanni Giuseppe Leoni, Merve N Güler, Tuğçe Er, Elifnaz Eker, Tunca Deniz Yazıcı, Muhammed Sıddık Kılıç, N Ezgi Altınışık, Ecem Ayşe Çelik, Pedro Morell Miranda, Marianne Dehasque, Viviana Floridia, Anders Götherström, C Can Bilgin, İnci Togan, Torsten Günther, Füsun Özer, Eleftherios Hadjisterkotis, Mehmet Somel (2024) Genome Biology and Evolution 2024;, evae090
Comparison and optimization of protocols and whole-genome capture conditions for ancient DNA samples
Reyhan Yaka , Maja Krzewińska, Vendela Kempe Lagerholm, Anna Linderholm, Füsun Özer, Mehmet Somel, Anders Götherström (2024) BioTechniques. 10.2144/btn-2023-0107
Gözde Atağ, Mehmet Somel (2024) bioRxiv 2024.02.17.580509
The time and place of origin of South Caucasian languages: insights into past human societies, ecosystems and human population genetics
Alexander Gavashelishvili, Merab Chukhua, Kakhi Sakhltkhutsishvili, Dilek Koptekin, Mehmet Somel (2023) Scientific Reports. 13. 10.1038/s41598-023-45500-w.
[PREPRINT] The first complete genome of the extinct European wild ass (Equus hemionus hydruntinus)
Gözde Atağ, Damla Kaptan, Eren Yüncü, Kıvılcım Başak Vural, Paolo Mereu, Monica Pirastru, Mario Barbato, Giovanni Giuseppe Leoni, Merve N. Güler, Tuğçe Er, Elifnaz Eker, Tunca Deniz Yazıcı, Muhammed Sıddık Kılıç, N. Ezgi Altınışık, Ecem Ayşe Çelik, Pedro Morell Miranda, Marianne Dehasque, Viviana Floridia, Anders Götherström, C. Can Bilgin, İnci Togan, Torsten Günther, Füsun Özer, Eleftherios Hadjisterkotis, Mehmet Somel (2023) bioRxiv 2023.11.23.568468
aMeta: an accurate and memory-efficient ancient Metagenomic profiling workflow
Zoé Pochon, Nora Bergfeldt, Emrah Kırdök, Mário Vicente, Thijessen Naidoo, Tom van der Valk, N. Ezgi Altınışık, Maja Krzewińska, Love Dalen, Anders Götherström, Claudio Mirabello, Per Unneberg, Nikolay Oskolkov (2023) Genome Biology 24, 242.
Single hybrid population but multiple parental individuals at the origin of parthenogenetic rock lizards Darevskia sapphirina and D. bendimahiensis Schmidtler, & Eiselt Darevsky (1994) endemic to the area of Lake Van in East Turkey
Meriç Erdolu, Mehmet Kürşat Şahin, Mehmet Somel, Alexey Yanchukov (2023) Molecular Phylogenetics and Evolution, 189, 107925.
[PREPRINT] The first complete genome of the extinct European wild ass (Equus hemionus hydruntinus)
Mustafa Özkan, Kanat Gürün, Eren Yüncü, Kıvılcım Başak Vural, Gözde Atağ, Ali Akbaba, Fatma Rabia Fidan, Ekin Sağlıcan, N. Ezgi Altınışık, Dilek Koptekin, Kamilla Pawłowska, Ian Hodder, Sarah E. Adcock, Benjamin S. Arbuckle, Sharon R. Steadman, Gregory McMahon, Yılmaz Selim Erdal, Cemal Can Bilgin, Eva-Maria Geigl, Anders Götherström, Thierry Grange, Füsun Özer, Mehmet Somel (2023) bioRxiv 2023.06.05.543765
[PREPRINT] Under the shadow: Old-biased genes are subject to weak purifying selection at both the tissue and cell type-specific levels
Melih Yıldız, Hamit İzgi, Firuza Rahimova, Umut Berkay Altıntaş, Zeliha Gözde Turan, Mehmet Somel (2022) bioRxiv 2022.09.21.508695
Mobility and kinship in the world’s first village societies
Jessica Pearson, Jane Evans, Angela Lamb, Douglas Baird, Ian Hodder, Arkadiusz Marciniak, Clark Spencer Larsen, Christopher J. Knüsel, Scott D. Haddow, Marin A. Pilloud, Amy Bogaard, Andrew Fairbairn, Jo-Hannah Plug, Camilla Mazzucato, Gökhan Mustafaoğlu, Michal Feldman, Mehmet Somel, Eva Fernández-Domínguez (2023) Proceedings of the National Academy of Sciences, 120(4), e2209480119.
CONGA: Copy number variation genotyping in ancient genomes and low-coverage sequencing data
Arda Söylev, Sevim Seda Çokoglu, Dilek Koptekin, Can Alkan, Mehmet Somel (2022) PLoS Computational Biology 18(12): e1010788
Spatial and temporal heterogeneity in human mobility patterns in Holocene Southwest Asia and the East Mediterranean
Dilek Koptekin, Eren Yüncü, Ricardo Rodríguez-Varela, N. Ezgi Altınışık, Nikolaos Psonis,Natalia Kashuba, Sevgi Yorulmaz, Robert George, Duygu Deniz Kazancı, Damla Kaptan, Kanat Gürün, Kıvılcım Başak Vural, Hasan Can Gemici, Despoina Vassou, Evangelia Daskalaki, Cansu Karamurat, Vendela K. Lagerholm, Ömür Dilek Erdal, Emrah Kırdök, Aurelio Marangoni, Andreas Schachner, Handan Üstündağ, Ramaz Shengelia, Liana Bitadze, Mikheil Elashvili, Eleni Stravopodi, Mihriban Özbaşaran, Güneş Duru, Argyro Nafplioti, C. Brian Rose, Tuğba Gencer, Gareth Darbyshire, Alexander Gavashelishvili, Konstantine Pitskhelauri, Özlem Çevik, Osman Vuruşkan, Nina Kyparissi-Apostolika, Ali Metin Büyükkarakaya, Umay Oğuzhanoğlu, Sevinç Günel, Eugenia Tabakaki, Akper Aliev, Anar Ibrahimov, Vaqif Shadlinski, Adamantios Sampson, Gülşah Merve Kılınç, Çiğdem Atakuman, Alexandros Stamatakis, Nikos Poulakakis, Yılmaz Selim Erdal, Pavlos Pavlidis, Jan Storå, Füsun Özer, Anders Götherström, and Mehmet Somel (2022) Current Biology 33, 1-17
Somatic copy number variant load in neurons of healthy controls and Alzheimer’s disease patients
Zeliha Gözde Turan, Vincent Richter, Jana Bochmann, Poorya Parvizi, Etka Yapar, Ulaş Işıldak, Sarah-Kristin Waterholter, Sabrina Leclere-Turbant, Çağdaş Devrim Son, Charles Duyckaerts, İdil Yet, Thomas Arendt, Mehmet Somel, Uwe Ueberham (2022) Acta Neuropathologica Communications Volume 10, Article number: 175
Science and politics: The fight for evolution
N. Ezgi Altınışık (2022) eLife 11:e84343
A genomic snapshot of demographic and cultural dynamism in Upper Mesopotamia during the Neolithic Transition
N. Ezgi Altınışık, Duygu Deniz Kazancı, Ayça Aydoğan, Hasan Can Gemici, Ömür Dilek Erdal, Savaş Sarıaltun, Kıvılcım Başak Vural, Dilek Koptekin, Kanat Gürün, Ekin Sağlıcan, Daniel Fernandes, Gökhan Çakan, Meliha Melis Koruyucu, Vendela Kempe Lagerholm, Cansu Karamurat, Mustafa Özkan, Gülşah Merve Kılınç, Arda Sevkar, Elif Sürer, Anders Götherström, Çiğdem Atakuman, Yılmaz Selim Erdal, Füsun Özer, Aslı Erim Özdoğan, Mehmet Somel (2022) Science Advances, 8:44
MTaxi: A comparative tool for taxon identification of ultra low coverage ancient genomes
Gözde Atağ, Kıvılcım Başak Vural, Damla Kaptan, Mustafa Özkan, Dilek Koptekin, Ekin Sağlıcan, Sevcan Doğramacı, Mevlüt Köz, Ardan Yılmaz, Arda Söylev, İnci Togan, Mehmet Somel, Füsun Özer (2022) Open Res Europe, 2:100
New insights on commemoration of the dead through mortuary and architectural use of pigments at Neolithic Çatalhöyük, Turkey
Eline M. J. Schotsmans, G. Busacca, Sam Lin, Milena Vasić,, Rena Veropoulidou, Camilla Mazzucato, Belinda Tibbetts, Scott Donald Haddow, Mehmet Somel, F. Toksoy-Köksal, Christopher J. Knüsel, Marco Milella (2022) Scientific Reports
Indian genetic heritage in Southeast Asian populations
Piya Changmai, Kitipong Jaisamut, Jatupol Kampuansai, Wibhu Kutanan, N. Ezgi Altınışık, Olga Flegontova, Angkhana Inta, Eren Yüncü, Worrawit Boonthai, Horolma Pamjav, David Reich, Pavel Flegontov (2022) PLoS Genetics
Inter-tissue convergence of gene expression during ageing suggests age-related loss of tissue and cellular identity
Hamit İzgi, Dingding Han, Ulaş Işıldak, Shuyun Huang, Ece Kocabıyık, Philipp Khaitovich, Mehmet Somel, Handan Melike Dönertaş (2022) eLife 11:e68048
From bones to genomes: Current research on the population history of prehistoric Anatolia
Duygu Deniz Kazancı, Ezgi Altınışık, Ayça Aydoğan, Füsun Özer, Elif Sürer, Çiğdem Atakuman, Mehmet Somel, Yılmaz Selim Erdal (2021) In The Archaeology of Anatolia, Volume IV: Recent Discoveries (2018–2020). Sharon R. Steadman, Gregory McMahon (Eds.) Cambridge Scholars Publishing, Cambridge
Collaborate equitably in ancient DNA research and beyond
Mehmet Somel, N. Ezgi Altınışık, Füsun Özer, María C. Ávila-Arcos (2021) Nature
Archaeogenetic analysis of Neolithic sheep from Anatolia suggests a complex demographic history since domestication
Erinç Yurtman, Onur Özer, Eren Yüncü, Nihan Dilşad Dağtaş, Dilek Koptekin, Yasin Gökhan Çakan, Mustafa Özkan, Ali Akbaba, Damla Kaptan, Gözde Atağ, Kıvılcım Başak Vural, Can Yümni Gündem, Louise Martin, Gülşah Merve Kılınç, Ayshin Ghalichi, Sinan Can Açan, Reyhan Yaka, Ekin Sağlıcan, Vendela Kempe Lagerholm, Maja Krzewińska, Torsten Günther, Pedro Morell Miranda, Evangelia Pişkin, Müge Şevketoğlu, C. Can Bilgin, Çiğdem Atakuman, Yılmaz Selim Erdal, Elif Sürer, N. Ezgi Altınışık, Johannes A. Lenstra, Sevgi Yorulmaz, Mohammad Foad Abazari, Javad Hoseinzadeh, Douglas Baird, Erhan Bıçakçı, Özlem Çevik, Fokke Gerritsen, Rana Özbal, Anders Götherström, Mehmet Somel, İnci Togan & Füsun Özer (2021) Communications Biology
Human inbreeding has decreased in time through the Holocene
Francisco C. Ceballos, Kanat Gürün, N. Ezgi Altınışık, Hasan Can Gemici, Cansu Karamurat, Dilek Koptekin, Kıvılcım Başak Vural, Igor Mapelli, Ekin Sağlıcan, Elif Sürer, Yılmaz Selim Erdal, Anders Götherström, Füsun Özer, Çiğdem Atakuman, Mehmet Somel (2021) Current Biology
Variable kinship patterns in Neolithic Anatolia revealed by ancient genomes
Reyhan Yaka, Igor Mapelli, Damla Kaptan, Ayça Doğu, Maciej Chyleński, Ömür Dilek Erdal, Dilek Koptekin, Kıvılcım Başak Vural, Alex Bayliss, Camilla Mazzucato, Evrim Fer, Sevim Seda Çokoğlu, Vendela Kempe Lagerholm, Maja Krzewińska, Cansu Karamurat, Hasan Can Gemici,
Arda Sevkar, Nihan Dilşad Dağtaş, Gülşah Merve Kılınç, Donovan Adams, Arielle R. Munters, Ekin Sağlıcan, Marco Milella, Eline M.J. Schotsmans, Erinç Yurtman, Mehmet Çetin, Sevgi Yorulmaz, N. Ezgi Altınışık, Ayshin Ghalichi, Anna Juras, C. Can Bilgin, Torsten Günther, Jan Storå, Mattias Jakobsson, Maurice de Kleijn, Gökhan Mustafaoğlu, Andrew Fairbairn, Jessica Pearson, İnci Togan, Nurcan Kayacan, Arkadiusz Marciniak, Clark Spencer Larsen, Ian Hodder, Çiğdem Atakuman, Marin Pilloud, Elif Sürer, Fokke Gerritsen, Rana Özbal, Douglas Baird Yılmaz Selim Erdal, Güneş Duru, Mihriban Özbaşaran, Scott D. Haddow, Christopher J. Knüsel, Anders Götherström, Füsun Özer, Mehmet Somel (2021) Current Biology
Million-year-old DNA sheds light on the genomic history of mammoths
Tom van der Valk, Patrícia Pečnerová, David Díez-Del-Molino, Anders Bergström, Jonas Oppenheimer, Stefanie Hartmann, Georgios Xenikoudakis, Jessica A Thomas, Marianne Dehasque, Ekin Sağlıcan, Fatma Rabia Fidan, Ian Barnes, Shanlin Liu, Mehmet Somel, Peter D Heintzman, Pavel Nikolskiy, Beth Shapiro, Pontus Skoglund, Michael Hofreiter, Adrian M Lister, Anders Götherström, Love Dalén (2021) Nature
Human population dynamics and Yersinia pestis in ancient northeast Asia
Gülşah Merve Kılınç, Natalija Kashuba, Dilek Koptekin, Nora Bergfeldt, Handan Melike Dönertaş, Ricardo Rodríguez-Varela, Dmitrij Shergin, Grigorij Ivanov, Dmitrii Kichigin, Kjunnej Pestereva, Denis Volkov, Pavel Mandryka, Artur Kharinskii, Alexey Tishkin, Evgenij Ineshin, Evgeniy Kovychev, Aleksandr Stepanov, Love Dalén, Torsten Günther, Emrah Kırdök, Mattias Jakobsson, Mehmet Somel, Maja Krzewińska, Jan Storå, Anders Götherströmn (2021) Science Advances
Distinguishing between recent balancing selection and incomplete sweep using deep neural networks
Ulaş Işıldak, Alessandro Stella, Matteo Fumagalli (2021) Molecular Ecology Resources
Ancient genomics in Neolithic Central Anatolia and Çatalhöyük
Reyhan Yaka, Ayça Doğu, Damla Kaptan, Nihan Dilşad Dağtaş, Maciej Chyleński, Kıvılcım Başak Vural, N. Ezgi Altınışık, Igor Mapelli, Dilek Koptekin, Cansu Karamurat, Hasan Can Gemici, Sevgi Yorulmaz, Vendela Kempe Lagerholm, Evrim Fer, Ulaş Işıldak, Ayshin Ghalichi, Gülşah Merve Kılınç, Camilla Mazzucato, Anna Juras, Arkadiusz Marciniak, Clark S. Larsen, Marin Pilloud, Scott D. Haddow, Christopher J. Knüsel, İnci Togan, Anders Götherström, Yılmaz Selim Erdal, Elif Sürer, Füsun Özer, Çiğdem Atakuman, Mehmet Somel (2021) in Peopling the Landscape of Çatalhöyük: Reports from the 2009-2017 Seasons. Hodder I. (Ed.) London: British Institute at Ankara.
Temporal changes in the gene expression heterogeneity during brain development and aging
Ulaş Işıldak, Mehmet Somel, Janet M. Thornton & Handan Melike Dönertaş (2020) Scientific Reports
Molecular footprint of Medawar’s mutation accumulation process in mammalian aging
Zeliha Gözde Turan, Poorya Parvizi, Handan Melike Dönertaş, Jenny Tung, Philipp Khaitovich, Mehmet Somel (2019) Aging Cell
Ancient mitochondrial genomes reveal the absence of maternal kinship in the burials of Çatalhöyük people and their genetic affinities
Maciej Chyleński, Edvard Ehler, Mehmet Somel, Reyhan Yaka, Maja Krzewińska, Mirosława Dabert,Anna Juras, Arkadiusz Marciniak (2019) Genes
Ancient genomes suggest the eastern Pontic-Caspian steppe as the source of western Iron Age nomads
Maja Krzewińska, Gülşah Merve Kılınç, Anna Juras, Dilek Koptekin, Maciej Chyleński, Alexey G. Nikitin, Nikolai Shcherbakov, Iia Shuteleva, Tatiana Leonova, Liudmila Kraeva, Flarit A. Sungatov, Alfija N. Sultanova, Inna Potekhina, Sylwia Łukasik, Marta Krenz-Niedbała, Love Dalén, Vitaly Sinika,Mattias Jakobsson,Jan Storå, Anders Götherström (2018) Science Advance
Genomic and strontium isotope variation reveal immigration patterns in a Viking Age town
Maja Krzewińska, Anna Kjellström, Torsten Günther, Charlotte Hedenstierna-Jonson, Torun Zachrisson, Ayça Omrak, Reyhan Yaka, Gülşah Merve Kılınç, Mehmet Somel, Veronica Sobrado, Jane Evans, Corina Knipper, Mattias Jakobsso, Jan Storå, Anders Götherström (2018) Current Biology
Investigating Holocene human population history in North Asia using ancient mitogenomes
Gülşah Merve Kılınç, Natalija Kashuba, Reyhan Yaka, Arev Pelin Sümer, Eren Yüncü,Dmitrij Shergin, Grigorij Leonidovich Ivanov, Dmitrii Kichigin, Kjunnej Pestereva, Denis Volkov, Pavel Mandryka, Artur Kharinskii, Alexey Tishkin, Evgenij Ineshin, Evgeniy Kovychev, Aleksandr Stepanov, Aanatolij Alekseev, Svetlana Aleksandrovna, Mehmet Somel, Mattias Jakobsson, Maja Krzewinska, Jan Storå, Anders Götherström (2018) Nature Scientific Reports
Archaeogenetics of Late Iron Age Çemialo Sırtı, Batman: Investigating maternal genetic continuity in north Mesopotamia since the Neolithic
Reyhan Yaka, Ayşegül Birand, Çigdem Atakuman, Yasemin Yılmaz, Ceren Caner, Sinan Can Açan, Sidar Gündüzalp, Poorya Parvizi, Aslı Erim Özdoğan, İnci Togan, Mehmet Somel (2018) American Journal of Physical Anthropology
Archaeogenomic analysis of the first steps of Neolithization in Anatolia and the Aegean
Gülşah Merve Kılınç, Dilek Koptekin , Çigdem Atakuman, Arev Pelin Sümer, Reyhan Yaka, Cemal Can Bilgin, Ali Metin Büyükkarakaya, Douglas Baird, Ezgi Altınışık, Pavel Flegontov, Anders Göthersthorm, İnci Togan, Mehmet Somel (2017) Proceedings of the Royal Society B
Variation and functional impact of Neanderthal ancestry in Western Asia
Recep Özgür Taskent, Nurşen Duha Alioğlu, Evrim Fer, Handan Melike Dönertaş, Mehmet Somel, Ömer Gökçümen (2017) Genome Biology and Evolution
Gene expression reversal toward pre-adult levels in the aging human brain and age-related loss of cellular identity
Handan Melike Dönertaş, Hamit İzgi, Altuğ Kamacıoğlu, Zhisong He, Philipp Khaitovich, Mehmet Somel (2017) Scientific Reports
The demographic development of the first farmers in Anatolia
Gülşah Merve Kılınç, Ayça Omrak, Füsun Özer, Torsten Günther, Ali Metin Büyükkarakaya, Erhan Bıçakçı, Douglas Baird, Handan Melike Dönertaş, Ayshin Ghalichi, Reyhan Yaka, Dilek Koptekin, Sinan Can Açan, Poorya Parvizi, Maja Krzewinska, Evangelia A. Daskalaki, Eren Yüncü, Nihan Dilşad Dağtaş, Andrew Fairbairn, Jessica Pearson, Gökhan Mustafaoğlu, Yılmaz Selim Erdal, Yasin Gökhan Çakan, İnci Togan, Mehmet Somel, Jan Storå, Mattias Jakobsson, Anders Götherström (2016) Current Biology
Determining the origin of synchronous multifocal bladder cancer by exome sequencing
Ömer Acar, Ezgi Özkurt, Gülfem Demir, Hilal Saraç, Can Alkan, Tarık Esen, Mehmet Somel, Nathan A. Lack (2015) BMC Cancer
Whole genome sequencing of Turkish genomes reveals functional private alleles and impact of genetic interactions with Europe, Asia and Africa
Can Alkan, Pınar Kavak, Mehmet Somel, Ömer Gökçümen, Serkan Uğurlu, Ceren Saygı, Elif Dal, Kuyaş Buğra, Tunga Güngör, S Cenk Şahinalp, Nesrin Özören, Cemalettin Bekpen (2014) BMC Genomics
Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA
Emilia Huerta-Sánchez, Xin Jin, Asan, Zhuoma Bianba, Benjamin M. Peter, Nicolas Vinckenbosch, Yu Liang, Xin Yi, Mingze He, Mehmet Somel, Peixiang Ni, Bo Wang, Xiaohua Ou, Huasang, Jiangbai Luosang, Zha Xi Ping Cuo, Kui Li, Guoyi Gao, Ye Yin, Wei Wang, Xiuqing Zhang, Xun Xu, Huanming Yang, Yingrui Li, Jian Wang, Jun Wang, Rasmus Nielsen (2014) Nature
Shared signatures of social stress and aging in peripheral blood mononuclear cell gene expression profiles
Noah Snyder-Mackler, Mehmet Somel, Jenny Tung (2014) Aging Cell
Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears
Shiping Liu, Eline D Lorenzen, Matteo Fumagalli, Bo Li, Kelley Harris, Zijun Xiong, Long Zhou, Thorfinn Sand Korneliussen, Mehmet Somel, Courtney Babbitt, Greg Wray, Jianwen Li, Weiming He, Zhuo Wang, Wenjing Fu, Xueyan Xiang, Claire C Morgan, Aoife Doherty, Mary J O’Connell, James O McInerney, Erik W Born, Love Dalén, Rune Dietz, Ludovic Orlando, Christian Sonne, Guojie Zhang, Rasmus Nielsen, Eske Willerslev, Jun Wang (2014) Cell
Classic selective sweeps revealed by massive sequencing in cattle
Saber Qanbari, Hubert Pausch Sandra Jansen, Mehmet Somel, Tim M Strom, Ruedi Fries, Rasmus Nielsen, Henner Simianer (2014) PLoS Genetics
Evolution of human longevity uncoupled from caloric restriction mechanisms
Guodong Zhao, Song Guo, Mehmet Somel, Philipp Khaitovich (2014) PLoS ONE
Mitochondrial DNA diversity of modern, ancient and wild sheep (Ovis gmelinii anatolica) from Turkey: new insights on the evolutionary history of sheep
Sevgin Demirci, Evren Koban Baştanlar, Nihan Dilşad Dağtaş, Evangelia Pişkin, Atilla Engin, Füsun Özer, Eren Yüncü, Şükrü Anıl Doğan, İnci Togan (2013) PLoS One
A scan for human-specific relaxation of negative selection reveals unexpected polymorphism in proteasome genes
Mehmet Somel, Melissa A Wilson Sayres, Gregory Jordan, Emilia Huerta-Sanchez, Matteo Fumagalli, Anna Ferrer-Admetlla, Rasmus Nielsen (2013) Molecular Biology & Evolution
Mechanisms of dietary response in mice and primates: A role for EGR1 in regulating the reaction to human-specific nutritional content
Kai Weng, Haiyang Hu, Augix Guohua Xu, Philipp Khaitovich, Mehmet Somel (2012) PLoS ONE
Accelerated aging-related transcriptome changes in the female prefrontal cortex
Yuan Yuan, Yi-Ping Phoebe Chen, Jerome Boyd-Kirkup, Philipp Khaitovich, Mehmet Somel (2012) Aging Cell
Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques
Xiling Liu, Mehmet Somel, Lin Tang, Zheng Yan, Xi Jiang, Song Guo, Yuan Yuan, Liu He, Anna Oleksiak, Yan Zhang, Na Li, Yuhui Hu, Wei Chen, Zilong Qiu, Svante Pääbo, Philipp Khaitovich (2012) Genome Research
MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates
Somel M, Liu X, Tang L, Yan Z, Hu HY, Guo S, Xu GH, Xie GC, Li N, Hu Y, Chen W, Pääbo S, Khaitovich P (2011) PLoS Biology
Development and application of a modified dynamic time warping algorithm (DTW-S) to analyses of primate brain expression time series
Yuan Y, Chen YP, Ni S, Xu AG, Tang L, Vingron M, Somel M, Khaitovich P (2011) BMC Bioinformatics
MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain
Yuan Yuan, Yi-Ping Phoebe Chen, Shengyu Ni, Augix Guohua Xu, Lin Tang, Martin Vingron, Mehmet Somel, Philipp Khaitovich (2010) Genome Research
The role of neoteny in human evolution: from genes to the phenotype
Mehmet Somel, Lin Tang, Philipp Khaitovich (2010) In Post-Genome Biology of Primates. H. Hirai, H. Imai,Y. Go (Eds.). Springer, Berlin
Transcriptional neoteny in the human brain
Mehmet Somel, Henriette Franz, Zheng Yan, Anna Lorenc, Song Guo, Thomas Giger, Janet Kelso, Birgit Nickel, Michael Dannemann, Sabine Bahn, Maree J Webster, Cynthia S Weickert, Michael Lachmann, Svante Pääbo, Philipp Khaitovich (2008) PNAS
Human and chimpanzee gene expression differences replicated in mice fed different diets
Mehmet Somel, Hilliary Creely, Henriette Franz, Uwe Mueller, Michael Lachmann, Philipp Khaitovich, Svante Pääbo (2008) PLoS ONE
Gene expression becomes heterogeneous with age
Mehmet Somel, Philipp Khaitovich, Sabine Bahn, Svante Pääbo, Michael Lachmann (2006) Current Biology