Publications

New insights on commemoration of the dead through mortuary and architectural use of pigments at Neolithic Çatalhöyük, Turkey
Eline M. J. Schotsmans, G. Busacca, Sam Lin, Milena Vasić,, Rena Veropoulidou, Camilla Mazzucato, Belinda Tibbetts, Scott Donald Haddow, Mehmet Somel, F. Toksoy-Köksal, Christopher J. Knüsel, Marco Milella (2022) Scientific Reports

Indian genetic heritage in Southeast Asian populations
Piya Changmai, Kitipong Jaisamut, Jatupol Kampuansai, Wibhu Kutanan, N. Ezgi Altınışık, Olga Flegontova, Angkhana Inta, Eren Yüncü, Worrawit Boonthai, Horolma Pamjav, David Reich, Pavel Flegontov (2022) PLoS Genetics

From bones to genomes: Current research on the population history of prehistoric Anatolia
Duygu Deniz Kazancı, Ezgi Altınışık, Ayça Aydoğan, Füsun Özer, Elif Sürer, Çiğdem Atakuman, Mehmet Somel, Yılmaz Selim Erdal (2021) In The Archaeology of Anatolia, Volume IV: Recent Discoveries (2018–2020). Sharon R. Steadman, Gregory McMahon (Eds.) Cambridge Scholars Publishing, Cambridge

Archaeogenetic analysis of Neolithic sheep from Anatolia suggests a complex demographic history since domestication
Erinç Yurtman, Onur Özer, Eren Yüncü, Nihan Dilşad Dağtaş, Dilek Koptekin, Yasin Gökhan Çakan, Mustafa Özkan, Ali Akbaba, Damla Kaptan, Gözde Atağ, Kıvılcım Başak Vural, Can Yümni Gündem, Louise Martin, Gülşah Merve Kılınç, Ayshin Ghalichi, Sinan Can Açan, Reyhan Yaka, Ekin Sağlıcan, Vendela Kempe Lagerholm, Maja Krzewińska, Torsten Günther, Pedro Morell Miranda, Evangelia Pişkin, Müge Şevketoğlu, C. Can Bilgin, Çiğdem Atakuman, Yılmaz Selim Erdal, Elif Sürer, N. Ezgi Altınışık, Johannes A. Lenstra, Sevgi Yorulmaz, Mohammad Foad Abazari, Javad Hoseinzadeh, Douglas Baird, Erhan Bıçakçı, Özlem Çevik, Fokke Gerritsen, Rana Özbal, Anders Götherström, Mehmet Somel, İnci Togan & Füsun Özer (2021) Communications Biology

Human inbreeding has decreased in time through the Holocene
Francisco C. Ceballos, Kanat Gürün, N. Ezgi Altınışık, Hasan Can Gemici, Cansu Karamurat, Dilek Koptekin, Kıvılcım Başak Vural, Igor Mapelli, Ekin Sağlıcan, Elif Sürer, Yılmaz Selim Erdal, Anders Götherström, Füsun Özer, Çiğdem Atakuman, Mehmet Somel (2021) Current Biology

Variable kinship patterns in Neolithic Anatolia revealed by ancient genomes
Reyhan Yaka, Igor Mapelli, Damla Kaptan, Ayça Doğu, Maciej Chyleński, Ömür Dilek Erdal, Dilek Koptekin, Kıvılcım Başak Vural, Alex Bayliss, Camilla Mazzucato, Evrim Fer, Sevim Seda Çokoğlu, Vendela Kempe Lagerholm, Maja Krzewińska, Cansu Karamurat, Hasan Can Gemici,
Arda Sevkar, Nihan Dilşad Dağtaş, Gülşah Merve Kılınç, Donovan Adams, Arielle R. Munters, Ekin Sağlıcan, Marco Milella, Eline M.J. Schotsmans, Erinç Yurtman, Mehmet Çetin, Sevgi Yorulmaz, N. Ezgi Altınışık, Ayshin Ghalichi, Anna Juras, C. Can Bilgin, Torsten Günther, Jan Storå, Mattias Jakobsson, Maurice de Kleijn, Gökhan Mustafaoğlu, Andrew Fairbairn, Jessica Pearson, İnci Togan, Nurcan Kayacan, Arkadiusz Marciniak, Clark Spencer Larsen, Ian Hodder, Çiğdem Atakuman, Marin Pilloud, Elif Sürer, Fokke Gerritsen, Rana Özbal, Douglas Baird Yılmaz Selim Erdal, Güneş Duru, Mihriban Özbaşaran, Scott D. Haddow, Christopher J. Knüsel, Anders Götherström, Füsun Özer, Mehmet Somel (2021) Current Biology

Million-year-old DNA sheds light on the genomic history of mammoths
Tom van der Valk, Patrícia Pečnerová, David Díez-Del-Molino, Anders Bergström, Jonas Oppenheimer, Stefanie Hartmann, Georgios Xenikoudakis, Jessica A Thomas, Marianne Dehasque, Ekin Sağlıcan, Fatma Rabia Fidan, Ian Barnes, Shanlin Liu, Mehmet Somel, Peter D Heintzman, Pavel Nikolskiy, Beth Shapiro, Pontus Skoglund, Michael Hofreiter, Adrian M Lister, Anders Götherström, Love Dalén (2021) Nature

Human population dynamics and Yersinia pestis in ancient northeast Asia
Gülşah Merve Kılınç, Natalija Kashuba, Dilek Koptekin, Nora Bergfeldt, Handan Melike Dönertaş, Ricardo Rodríguez-Varela, Dmitrij Shergin, Grigorij Ivanov, Dmitrii Kichigin, Kjunnej Pestereva, Denis Volkov, Pavel Mandryka, Artur Kharinskii, Alexey Tishkin, Evgenij Ineshin, Evgeniy Kovychev, Aleksandr Stepanov, Love Dalén, Torsten Günther, Emrah Kırdök, Mattias Jakobsson, Mehmet Somel, Maja Krzewińska, Jan Storå, Anders Götherströmn (2021) Science Advances

Distinguishing between recent balancing selection and incomplete sweep using deep neural networks
Ulaş Işıldak, Alessandro Stella, Matteo Fumagalli (2021) Molecular Ecology Resources

Ancient genomics in Neolithic Central Anatolia and Çatalhöyük
Yaka, R., Doğu, A., Kaptan, D., Dağtaş, N. D., Chyleński, M., Vural, K. B., Altınışık, N. E., Mapelli, I., Koptekin, D., Karamurat, C., Gemici, H. C., Yorulmaz, S., Lagerholm, V. K., Fer, E., Işıldak, U., Ghalichi, A., Kılınç, G. M., Mazzucato, C., Juras, A., Marciniak, A., Larsen, C. S., Pilloud, M., Haddow, S. D., Knüsel, C. J., Togan, İ, Götherström, A., Erdal, Y. S., Sürer, E., Özer, F., Atakuman, Ç., and Somel, M. (2021) (2021), in Hodder I. (ed.) Peopling the Landscape of Çatalhöyük: Reports from the 2009-2017 Seasons. London: British Institute at Ankara.

Temporal changes in the gene expression heterogeneity during brain development and aging
Ulaş Işıldak,
Mehmet Somel, Janet M. Thornton & Handan Melike Dönertaş (2020) Scientific Reports

Molecular footprint of Medawar’s mutation accumulation process in mammalian aging
Zeliha Gözde Turan, Poorya Parvizi, Handan Melike Dönertaş, Jenny Tung, Philipp Khaitovich, Mehmet Somel (2019) Aging Cell

Ancient mitochondrial genomes reveal the absence of maternal kinship in the burials of Çatalhöyük people and their genetic affinities
Maciej Chyleński, Edvard Ehler, Mehmet Somel, Reyhan Yaka, Maja Krzewińska, Mirosława Dabert,Anna Juras, Arkadiusz Marciniak (2019) Genes

Ancient genomes suggest the eastern Pontic-Caspian steppe as the source of western Iron Age nomads
Maja Krzewińska, Gülşah Merve Kılınç, Anna Juras, Dilek Koptekin, Maciej Chyleński, Alexey G. Nikitin, Nikolai Shcherbakov,  Iia ShutelevaTatiana Leonova, Liudmila Kraeva, Flarit A. SungatovAlfija N. Sultanova, Inna Potekhina, Sylwia Łukasik, Marta Krenz-Niedbała, Love Dalén, Vitaly Sinika,Mattias Jakobsson,Jan Storå, Anders Götherström (2018) Science Advance

Genomic and strontium isotope variation reveal immigration patterns in a Viking Age town
Maja Krzewińska, Anna Kjellström, Torsten Günther, Charlotte Hedenstierna-Jonson, Torun Zachrisson, Ayça Omrak, Reyhan Yaka, Gülşah Merve Kılınç, Mehmet Somel, Veronica Sobrado, Jane Evans, Corina Knipper, Mattias Jakobsso, Jan Storå, Anders Götherström (2018) Current Biology

Investigating Holocene human population history in North Asia using ancient mitogenomes
Gülşah Merve Kılınç, Natalija Kashuba, Reyhan Yaka, Arev Pelin Sümer, Eren Yüncü,Dmitrij Shergin, Grigorij Leonidovich Ivanov, Dmitrii Kichigin, Kjunnej Pestereva, Denis Volkov, Pavel Mandryka, Artur Kharinskii, Alexey Tishkin, Evgenij Ineshin, Evgeniy Kovychev, Aleksandr Stepanov, Aanatolij Alekseev, Svetlana Aleksandrovna, Mehmet Somel, Mattias Jakobsson, Maja Krzewinska, Jan Storå, Anders Götherström (2018) Nature Scientific Reports

Archaeogenetics of Late Iron Age Çemialo Sırtı, Batman: Investigating maternal genetic continuity in north Mesopotamia since the Neolithic
Reyhan Yaka, Ayşegül Birand, Çigdem Atakuman, Yasemin Yılmaz, Ceren Caner, Sinan Can Açan, Sidar Gündüzalp, Poorya Parvizi, Aslı Erim Özdoğan, İnci Togan, Mehmet Somel (2018) American Journal of Physical Anthropology

Archaeogenomic analysis of the first steps of Neolithization in Anatolia and the Aegean
Gülşah Merve Kılınç, Dilek Koptekin , Çigdem Atakuman, Arev Pelin Sümer, Reyhan Yaka, Cemal Can Bilgin, Ali Metin Büyükkarakaya, Douglas Baird, Ezgi Altınışık, Pavel Flegontov, Anders Göthersthorm,İnci Togan, Mehmet Somel (2017) Proceedings of the Royal Society B

Variation and functional impact of Neanderthal ancestry in Western Asia
Recep Özgür Taskent, Nurşen Duha Alioğlu, Evrim Fer, Handan Melike Dönertaş, Mehmet Somel, Ömer Gökçümen (2017) Genome Biology and Evolution

Gene expression reversal toward pre-adult levels in the aging human brain and age-related loss of cellular identity
Handan Melike Dönertaş, Hamit İzgi, Altuğ Kamacıoğlu, Zhisong He, Philipp Khaitovich, Mehmet Somel (2017) Scientific Reports

The demographic development of the first farmers in Anatolia
Gülşah Merve Kılınç, Ayça Omrak, Füsun Özer, Torsten Günther, Ali Metin Büyükkarakaya, Erhan Bıçakçı, Douglas Baird, Handan Melike Dönertaş, Ayshin Ghalichi, Reyhan Yaka, Dilek Koptekin, Sinan Can Açan, Poorya Parvizi, Maja Krzewinska, Evangelia A. Daskalaki, Eren Yüncü, Nihan Dilşad Dağtaş, Andrew Fairbairn, Jessica Pearson, Gökhan Mustafaoğlu, Yılmaz Selim Erdal, Yasin Gökhan Çakan, İnci Togan, Mehmet Somel, Jan Storå, Mattias Jakobsson, Anders Götherström (2016) Current Biology

Determining the origin of synchronous multifocal bladder cancer by exome sequencing
Ömer Acar, Ezgi Özkurt, Gülfem Demir, Hilal Saraç, Can Alkan, Tarık Esen, Mehmet Somel, Nathan A. Lack (2015) BMC Cancer

Whole genome sequencing of Turkish genomes reveals functional private alleles and impact of genetic interactions with Europe, Asia and Africa
Can Alkan, Pınar Kavak, Mehmet Somel, Ömer Gökçümen, Serkan Uğurlu, Ceren Saygı, Elif Dal, Kuyaş Buğra, Tunga Güngör, S Cenk Şahinalp, Nesrin Özören, Cemalettin Bekpen (2014) BMC Genomics

Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA
Emilia Huerta-Sánchez, Xin Jin, Asan, Zhuoma Bianba, Benjamin M. Peter, Nicolas Vinckenbosch, Yu Liang, Xin Yi, Mingze He, Mehmet Somel, Peixiang Ni, Bo Wang, Xiaohua Ou, Huasang, Jiangbai Luosang, Zha Xi Ping Cuo, Kui Li, Guoyi Gao, Ye Yin, Wei Wang, Xiuqing Zhang, Xun Xu, Huanming Yang, Yingrui Li, Jian Wang, Jun Wang, Rasmus Nielsen (2014) Nature

Shared signatures of social stress and aging in peripheral blood mononuclear cell gene expression profiles
Noah Snyder-Mackler, Mehmet Somel, Jenny Tung (2014) Aging Cell

Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears
Shiping Liu, Eline D Lorenzen, Matteo Fumagalli, Bo Li, Kelley Harris, Zijun Xiong, Long Zhou, Thorfinn Sand Korneliussen, Mehmet Somel, Courtney Babbitt, Greg Wray, Jianwen Li, Weiming He, Zhuo Wang, Wenjing Fu, Xueyan Xiang, Claire C Morgan, Aoife Doherty, Mary J O’Connell, James O McInerney, Erik W Born, Love Dalén, Rune Dietz, Ludovic Orlando, Christian Sonne, Guojie Zhang, Rasmus Nielsen, Eske Willerslev, Jun Wang (2014) Cell

Classic selective sweeps revealed by massive sequencing in cattle
Saber Qanbari, Hubert Pausch Sandra Jansen, Mehmet Somel, Tim M Strom, Ruedi Fries, Rasmus Nielsen, Henner Simianer (2014) PLoS Genetics

Evolution of human longevity uncoupled from caloric restriction mechanisms
Guodong Zhao, Song Guo, Mehmet Somel, Philipp Khaitovich (2014) PLoS ONE

Mitochondrial DNA diversity of modern, ancient and wild sheep (Ovis gmelinii anatolica) from Turkey: new insights on the evolutionary history of sheep
Sevgin Demirci, Evren Koban Baştanlar, Nihan Dilşad Dağtaş, Evangelia Pişkin, Atilla Engin, Füsun Özer, Eren Yüncü, Şükrü Anıl Doğan, İnci Togan (2013) PLoS One

A scan for human-specific relaxation of negative selection reveals unexpected polymorphism in proteasome genes
Mehmet Somel, Melissa A Wilson Sayres, Gregory Jordan, Emilia Huerta-Sanchez, Matteo Fumagalli, Anna Ferrer-Admetlla, Rasmus Nielsen (2013) Molecular Biology & Evolution

Mechanisms of dietary response in mice and primates: A role for EGR1 in regulating the reaction to human-specific nutritional content
Kai Weng, Haiyang Hu, Augix Guohua Xu, Philipp Khaitovich, Mehmet Somel (2012) PLoS ONE

Accelerated aging-related transcriptome changes in the female prefrontal cortex
Yuan Yuan, Yi-Ping Phoebe Chen, Jerome Boyd-Kirkup, Philipp Khaitovich, Mehmet Somel (2012) Aging Cell

Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques
Xiling Liu, Mehmet Somel, Lin Tang, Zheng Yan, Xi Jiang, Song Guo, Yuan Yuan, Liu He, Anna Oleksiak, Yan Zhang, Na Li, Yuhui Hu, Wei Chen, Zilong Qiu, Svante Pääbo, Philipp Khaitovich (2012) Genome Research

MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates
Somel M, Liu X, Tang L, Yan Z, Hu HY, Guo S, Xu GH, Xie GC, Li N, Hu Y, Chen W, Pääbo S, Khaitovich P (2011) PLoS Biology

Development and application of a modified dynamic time warping algorithm (DTW-S) to analyses of primate brain expression time series
Yuan Y, Chen YP, Ni S, Xu AG, Tang L, Vingron M, Somel M, Khaitovich P (2011) BMC Bioinformatics

MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain
Yuan Yuan, Yi-Ping Phoebe Chen, Shengyu Ni, Augix Guohua Xu, Lin Tang, Martin Vingron, Mehmet Somel, Philipp Khaitovich (2010) Genome Research

The role of neoteny in human evolution: from genes to the phenotype
Mehmet Somel, Lin Tang, Philipp Khaitovich (2010) In Post-Genome Biology of Primates. H. Hirai, H. Imai,Y. Go (Eds.). Springer, Berlin

Transcriptional neoteny in the human brain
Mehmet Somel, Henriette Franz, Zheng Yan, Anna Lorenc, Song Guo, Thomas Giger, Janet Kelso, Birgit Nickel, Michael Dannemann, Sabine Bahn, Maree J Webster, Cynthia S Weickert, Michael Lachmann, Svante Pääbo, Philipp Khaitovich (2008) PNAS

Human and chimpanzee gene expression differences replicated in mice fed different diets
Mehmet Somel, Hilliary Creely, Henriette Franz, Uwe Mueller, Michael Lachmann, Philipp Khaitovich, Svante Pääbo (2008) PLoS ONE

Gene expression becomes heterogeneous with age
Mehmet Somel, Philipp Khaitovich, Sabine Bahn, Svante Pääbo, Michael Lachmann (2006) Current Biology

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